Optimization of Monte Carlo Code for Clinical Simulation of Electron Beams

uptake distribution is flat across much of the sphere, with only a thin skin. This flat uptake behavior does not changewithmotion up to amplitudes of 10 mm . We have also developed a matrix of correction factors to the flat behavior for motion amplitudes and tumor volumes beyond these limits. Conclusion: Our data demonstrate for the first time, that true heterogeneity of NSCLC tumors can be modeled by SUVuptake which takes a Gaussian, Woods-Saxon or double-peaked functional form depending on tumor volume. The model we developed defines the “true” SUV distribution within tumor free of artifacts due to motion, and tumor volume and will therefore allow PET and potentially other metabolic studies to be optimally integrated into treatment plans. Author Disclosure: K. Wijesooriya: None. P. Peng: None. P.W. Read: None. T. Pan: None. A. Goode: None. P. Judy: None. S. Benedict: None. J.M. Larner: None.